Friday, April 28, 2006

NEW DRUG COMBINATION MIGHT BE A MORE EFFECTIVE PAIN RELIEVER

The nutritional supplement, glucosamine, boosts the pain relieving power of ibuprofen, according to a new study by Temple University researchers in the Journal of Pharmacology and Experimental Therapeutics (JPET). This new drug combination could one day allow patients to take a lower dose and get the same pain relief with fewer unwanted side effects.

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Good News for Knees

The researchers concluded that glucosamine relieved pain significantly better than the acetaminophen or placebo.

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Glucosamine works to stimulate joint function and repair

works to stimulate joint function and repair. It is most effective in treating osteoarthritis, the most prevalent type of arthritis. A number of studies over the last 20 years have shown this.

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Over-the-Counter Arthritis Drug Glucosamine Might Also Help Against MS

Glucosamine, the over-the counter natural product that has been touted to help with joint and cartilage problems associated with arthritis, may also provide some relief to individuals with multiple sclerosis (MS), a degenerative, nervous system disease with no known cure.

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Wednesday, April 19, 2006

Multiple Sclerosis - OTC Glucosamine may provide some relief

"Glucosamine, the over-the counter natural product that has been touted to help with joint and cartilage problems associated with arthritis ...."

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Natural Ways To Prevent & Treat Canine Arthritis

Natural Ways To Prevent & Treat Canine Arthritis

By: gene sower

Arthritis and bone disease are very common in dogs and usually take one of several types. These include hip dysplasia, dislocation of the kneecap, arthritis of the elbow, swelling and pain in the leg bones, and degeneration of the shoulder joint.

Hip dysplasia is a malformation of the hip sockets that allow excessive movement in the joint. This condition causes chronic inflammation and calcium deposits. Dislocation of the kneecap is a malformation of the leg bones which causes the kneecap to continually pull out of its place and slip back and forth, creating a low-grade inflammation. Arthritis of the elbow is a hereditary condition caused by improper bone formation. Swelling and pain in the leg bones is caused by insufficient production of vitamin C, which results in poor nutrition and heredity. Degeneration of the shoulder joint is the breakdown of cartilage in the shoulder causing inflammation and pain when moving.

These conditions are mostly hereditary and could be prevented if the female dog were fed properly throughout her pregnancy. The period of growth inside the uterus is most vital in terms of the formation of structure and essential tissues. Proper nutrition is a must during this stage. Try not to give your dog commercial foods and only feed natural and wholesome meals and snacks.

Giving your dog vitamin C on a regular basis also decreases or prevents some of these conditions from developing. Supply your dog with 250 to 2,000 milligrams of vitamin C per day, depending on the age and size of your dog. For example, a small Chihuahua puppy should get a dose of 250 milligrams per day and a large Doberman would get a dose of 500 milligrams per day.

Prevention is vital in order to prevent the development of these conditions. However, if any of the condition already exists, there are several things that you can do to decrease your dog’s pain and discomfort. The first step to proper treatment is to feed your dog with natural diet as much as possible. Include vitamin C per day, using between 500 to 2,000 milligrams depending on the size of the dog. Divide the daily amount and give it to your dog twice per day. Other vitamins and supplements that are important are combinations of vitamin A, vitamin D, and vitamin E. Also include raw grated vegetables in your dog’s diet, particularly celery, carrots, and beets.

In addition to providing your dog with good nutrition, you can also use natural treatments such as homeopathic and herbal remedies. These include glucosamine sulfate, Chondroitin and MSM. Consult with a vet specializing in natural health care to determine which one best fits your dog’s situation.

Article Source: http://www.articles-galore.com

Gene Sower is the publisher of the DOG BYTES newsletter and owner of www.naturalpetsworld.com, a site devoted to offering a huge selection of natural pet foods at discount prices.


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Pain Relief for Rheumatoid Arthritis

Pain Relief for Rheumatoid Arthritis

By: Trevor Mulholland

Rheumatoid arthritis is one of the most common forms of arthritis. In the United States alone, it affects about seven million individuals, most of them women. People of all ages can get this disease, but it usually manifests itself when one reaches his or her middle age. As with most other forms of arthritis, such as gout, osteoarthritis, and psoriatic arthritis, the rheumatoid version can cause extreme pain, limiting one's mobility and adversely affecting the patient's quality of life. Naturally, the issue of pain relief is a welcome topic for arthritis sufferers.

Rheumatoid arthritis is characterized by swelling and pain, and can affect the joints in the ankle, knee, foot, hand, and wrist. It has also been known to affect the spine as well. There is still some mystery as to what causes this disease, but science has been investigating the hormonal, environmental, and genetic factors that contribute to the condition's occurrence. What is known is that somehow, something goes haywire within the body's immune system and instead of protecting itself, it turns and attacks the joints -- hence its classification as an autoimmune disease.

The 19th-century French artist Pierre-August Renoir and comedienne Lucille Ball are only two of other famous people who have been victims of this disease. Like other patients, they most probably suffered from symptoms such as inflammation of a joint (which feels hot or tender to the touch), possibly fever and loss of weight, and a decline in the level of energy. But most of all, one's waking moments are characterized by unremitting pain, the most common symptom. That's why pain relief is not only desired but essential if one is to at least able to go on functioning in the most optimal way possible.

There are several pain killers prescribed by doctors for rheumatoid patients. Probably the most common medication is something called NSAIDs, the acronym for non-steroidal anti-inflammatory drugs. NSAIDs do not inhibit the progress of the disease, but they do a lot to reduce swelling and the associated pain. However, some NSAIDs, such as COX-2 inhibitors, have come under fire from the public because of significant side effects that they can cause, including kidney and heart problems. Corticosteroid drugs taken orally are prescribed in cases where the pain and inflammation are very severe; but again, there are potentially serious side effects associated with them, so they should not be taken without your physician's approval.

Because of the growing concern over side effects, many patients are turning to natural and alternative therapies to manage their symptoms. Natural treatment regimens for rheumatoid arthritis abound; involving substances ranging from gold to herbs to marine products. For instance, dandelion capsules and celery seeds are reputed to reduce uric acid levels in the body, and this is good because excessively high uric acid levels can exacerbate symptoms. Herbs like dong quai, boswellia, and sarsaparilla have anti-inflammatory properties which reduce swelling. There is also growing evidence that dietary supplements containing chondroitin and glucosamine are beneficial for arthritis sufferers -- but many medical experts caution their use for in the treatment of rheumatoid arthritis, saying they are only to be used by those suffering from osteoarthritis. Other natural therapeutic methods used to treat the disease include acupuncture, massage, and hydrotherapy.

Medical experts cannot emphasize strongly enough the importance of a healthy diet for those suffering from the disease. Studies show that patients usually do not have healthy eating habits, and that this disease occurs very rarely in cultures that do not thrive on fast food and other fatty foods. A diet based on whole foods, vegetables, fruits, and certain types of seafood is recommended; one that is rich in sugar, refined carbohydrates, saturated fat, and sugar is not. Surprisingly, some foods that are healthy can actually aggravate arthritic pain in some patients; these include dairy and wheat products, and vegetables like tomatoes and eggplants.

Exercise is another important factor in creating the foundation for arthritis management. Physical therapists will generally recommend exercises that are "joint-friendly," such as walking, riding a stationary bicycle, swimming and other water activities. Moving an affected joint in its full range of motion is recommended, as long as you keep the movement smooth to avoid inflicting pain. Exercise is good, but it should not be overdone because it will worsen the pain, not relieve it.

There is no cure as yet for rheumatoid arthritis. But with the right diet, exercise, and treatment, a large measure of pain relief can be achieved. It is a manageable condition that should not prevent a person from living a good-quality life and continue to function as a contributing member to society.

Article Source: http://www.articles-galore.com

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Glucosamine doesn't hurt blood glucose control.(The Diabetes Advisor)

Diabetes Forecast; 2/1/2004; Roberts, Shauna S.


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Friday, April 14, 2006

About Glucosamine

About Glucosamine
By J.R. Rogers
Glucosamine is an amino sugar produced from the shells of shellfish (chitin) and is a key component of the extra cellular matrix of cartilage. glucosamine works to stimulate joint function and repair. glucosamine has been clinically proven to slow the progression of osteoarthritis in humans with arthritis and hip dysplasia in pets. It has been proven effective in easing osteoarthritis pain, aid in rehabilitating cartilage, renewing synovial fluid, and repairing joints that have been damaged from osteoarthritis.

Our bodies produce glucosamine naturally. However, as we grow older we lose the ability to produce sufficient quantities. Having enough glucosamine is essential to producing the nutrients we need to produce synovial fluid. It is this fluid which lubricates our cartilage and maintains healthy joints.

When you have a glucosamine deficiency, cartilage hardens and bone spurs develop which leads to deformities in the joints. Your mobility becomes limited and in short, this is how osteoarthritis develops.

This was big news to nutraceutical companies and it was the beginning of an all-new segment of the industry. Today, nearly all of the major companies offer their version of glucosamine through a wide range of outlets, from retail stores to medical clinics.

However, in their rush to gain market share companies put products on the market with little regard to the overall quality of their offering. Most are deficient because the glucosamine ranges from low to medium quality at best. As well, most are in pill or capsule form which means that they are not absorbed well into your system.

The Science Backing Liquid Glucosamine formula Syn-flex®
The first tests on liquid glucosamine were completed in 1998. The testing made clear that the absorption rate and bio-availability of glucosamine in pill form was significantly less than in liquid form.

The misconception that pills are the only and best way to obtain glucosamine is simply not true. Pills and capsules contain glucosamine that is in powder form. It is a well known fact that liquid is absorbed much better than powder, at a rate of 80-85% absorption. In short, glucosamine in liquid form is absorbed faster and it provides greater impact.

The reports on the use of capsule or pill forms of glucosamine vary greatly. Most users report that if they received any relief at all, it came after six to ten weeks of use. On the other hand, those using liquid glucosamine reported feeling pain relief in as little as one to two weeks.

This is not the end of the story, however. glucosamine is most effective when combined with other synergistic ingredients. Syn-flex® is a 98% pure glucosamine formula that also combines 10 other synergistic arthritis-fighting ingredients for maximum pain relief, inflammation reduction, and cartilage rehabilitation.

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Thursday, April 13, 2006

Spotting Pain in your Pet

Spotting Pain in your Pet

By J. R. Rogers

Sometimes we take things for granted. We think we can spot pain when our pets experience it. With pets suffering from arthritis, it may or may not be easy to see.

Is it visible?

Most of us think of pets as demonstrating their pain. But, with pets suffering from arthritis, that is not as easy as it looks. Many of them are in pain long before they begin to show it.

Pets can develop arthritis very quickly. That is especially true with arthritis that is secondary to an injury. The early symptoms may not be as easy to spot as we think. For example, a pet may or may not show signs of limping or other unusual behavior. That makes our work a little tougher.

Major Symptoms

When a pet begins “showing” their pain, it may be a little late in the game. One that visibly limps may have had an injury with secondary arthritis much sooner than we thought. As noted, arthritis can be present even without overt symptoms.

Tried and True

I have always advocated the use of a very high-quality liquid Glucosamine to keep joints healthy. The rest is part of that entire package when it comes to keeping our pets comfortable: a sensible and arthritis-friendly diet, and some exercise.

How much is too much?

All pets love exercise. Even when they are not always feeling their best, they will often beg to go for a walk. So, the issue is not whether or not to exercise them but how far to take it. Of course, I have always said that you have to use a little judgment here. If they are getting tired or look as if they have had “too much” then a little less is better.

Safety Issues

We have talked about this before. The last thing a pet with arthritis needs is a slippery floor. It increases the risk of additional injuries. Cover floors like this with a rug to prevent the risk. Also, use runners where you may have a long hallway that is frequently used by your pet.

The risk of a “slip” by your pet can cause their legs to splay outward. This in turn can cause both muscle and joint injuries. It is a question of being responsible about these things. You almost have to look at areas of potential risk in and around your home.

This all becomes worse for an older pet because they almost always begin to develop anxieties as they age. Arthritic pets are especially vulnerable.

This may sound like pretty routine stuff but it can make a big difference to a pet. I know you care about their comfort and well being.

See you next time.

Wednesday, April 12, 2006

A Cautionary Note to Pet Owners.

A Cautionary Note to Pet Owners. By J. R. Rogers April 12, 2006

A Cautionary Note to Pet Owners

By J. R. Rogers

As our regular readers know, I offer up a lot of advice on dealing with arthritis in pets. This is a large part of my life.

However, from time to time I like to discuss other issues that deal with the safety and the well-being of your pet. Unfortunately, they are like children and are prone to getting themselves into harm’s way often.

Some Recent Reports about Human Medications

I was reading some articles that indicated that pets are accidentally ingesting human mediations and some with fatal consequences. In these articles, the discussion focused on a variety of anti-depressants and other mild to severe anxiety disorders.

The issue is that these medications are sometimes left where a pet might get a bottle open or they have been just dropped on the floor. There are many scenarios where a pet might find themselves simply eating or swallowing them.

Consequences

Pets are particularly at risk when ingesting these kinds of medications. It can rise to the level of a fatality that develops quickly. The thing is that symptoms can come on quickly and may not immediately alert the pet owner that this is the culprit.

The typical symptoms as reported are vomiting, diarrhea, abnormal heart rates, fluctuating blood pressure, and so on. Now, given that these kinds of symptoms may come from a variety of sources, the real responsibility lies with the pet owner.

What You Should Do

If you take any such medications, take the time to make certain you handle them carefully and that they are secured where pets cannot find them. If you are using such medications and see these kinds of symptoms arise, get to the vet. These situations require immediate attention.

I also find it interesting that vets report that they have treated pets that were given medications by pet owners to “calm them.” I am not sure why any responsible pet owner would take that kind of a risk but I know it happens.

I once had a woman call me and ask if she might give her pet (who suffered from arthritis) a drug in this class. She thought it might help calm the pet down. Of course, the answer is a resounding “no” and that is the way it should be.

In my experience, pets suffering from arthritis conditions are better served using a high-quality liquid Glucosamine, reasonable exercise, and a good diet. I have never personally seen any who need an anti-anxiety or depression medication. They just want their pain to ease.

A little common sense can go a long ways here.

See you next time.

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The Strain Factor

08/09/05 JR Rogers

As those who read this column know, I have recommendations that I know will help you to deal with the affects of arthritis. And, by now they are pretty well known.

First, use a high-quality liquid Glucosamine for pain relief and to maintain general joint health. Second, eat sensibly and keep your weight down. And finally, get some exercise.

Exercise
It is safe to say that most who have health issues should discuss any proposed exercise with their physicians. This is just being prudent. For those who have arthritis, there is an issue of "how much and what to do?"

Strain
If you have arthritis, whether Rheumatoid or Osteoarthritis you have to be a little cautious. I tend to lean toward the low-impact exercise regimens myself. After all, exercise is essential to maintaining joint strength but at the same time, a little caution is just common sense.

Exercise does put stress on joints. Make no mistake about that. For those with arthritis in the lower extremities like the hip or knee areas, you are getting far more body weight bearing on those affected joints.

How much is too much?
The issue of strain really turns on a number of factors but likely the most important is the extent of damage you are dealing with. If you have a lot of damage, it would be smart to stay with exercise that puts little stress on the joints; that is, of course, walking or any exercise you can get in water. Those are favorites of mine.

Exercise machines that are designed to emulate walking or even some with slight inclines are OK. Just don't push yourself too hard. Frankly, I never saw much need for these. There is no expense in going out for a walk. Far too many people invest in these devices only to sit and gather dust. I know all about that myself.

What you do not want to do!
If you have joint damage, the high-impact sports are out of the question. That is playing basketball, baseball or similar sports. Of course, many athletes who are in great physical condition often get by with continuing these activities by using a good liquid Glucosamine and being sensible in their approach. In general, those sports should be avoided if you have any concerns about joint damage.

I have said this before and will say it again, "exercise is essential to those who have arthritis and you do not have to go overboard." Just make certain that exercise is part of your lifestyle. It is usually best to begin slowly. And after reading all of these chronicles I am sure that some of you still haven't done it.

It never ceases to amaze me. Even when you know something is good for you it becomes something you avoid. It does not make a lot of sense to me. Why not give a little exercise a try? It only takes a minimal effort on your part and it can make a world of difference. More News On ...



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Hot and Cold Therapy

09/01/05 JR Rogers

Someone called me the other day to ask this question again. What do you do for a sudden injury? Do you use a "hot pack" or a "cold pack?"

This seems to be something that happens a lot so we might as well get this right. Of course, most athletes are already familiar with this but you may not be.

Sprains and Strains

Cold should be applied to both strains and sprains. Cold packs (or, whatever you use to administer) are best every 4-6 hours for a few days. The reason is that cold reduces inflammation. Also, there is often cellular damage when there is inflammation because it reduces the oxygen supply to the tissue.

Finally, when you apply "cold" to a sprain or strain it acts like an anesthetic. In short, it takes away the pain.

Compresses

There are a lot of them on the market and they can be purchased at drug stores and even grocery stores. However, if you do not have one, you can use a bag of frozen vegetables right out of a freezer. And, to protect your skin, you should wrap it in something such as a cloth, towel, or even a bag. Putting something that cold on your skin directly can cause frostbite and even some damage.

Heat Packs

You don't really put "heat" to work until swelling has gone down. Generally, this takes a day or two and it may take a little longer. What heat does is stimulate blood flow and also allows tightened muscles to relax.

Once again, you should use a regimen of about twenty minutes about three times daily. You can also accommodate this with bathing or using warm compresses.

The New Stuff on the Market

Of course, companies keep coming up with newer commercial versions of products to accommodate pain. These are special "wraps" and even some "patches" that you apply to the affected area. If you prefer to use those commercial packs, that is fine.

Arthritis Pain

Now, having said all of that, let's go back to arthritis pain. Generally speaking, you are better off using "cold therapy" for arthritis pain. That means other than a sprain or strain that occurs in an area other than an affected joint, should be handled using these instructions.

It would be nice if we never had to deal with these little annoyances at all. Unfortunately, we all do.

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For Arthritis, It is Just a Walk in the Park

11/01/05 JR Rogers

As you likely know, I have shared the three things that I feel give you the greatest success in dealing with osteoarthritis. First, that you use a high-quality liquid Glucosamine. Secondly, that you stay with a healthy diet regimen. Finally, that you exercise.

The Walk that Really Works

As a doctor recently told me, you do not need a great deal of exercise. The important thing is that you do it. Now, I have said before that walking is likely the easiest and of course, it is certainly not expensive.

Maximizing the Benefits of the Walk

Walking not only is good for arthritis sufferers, it also controls blood pressure and it is a great way to "exercise" your heart. What is interesting is that walking is considered to be a weight-bearing exercise. It assists with weight management and much more.

If you really want to get the greatest benefits out of walking, here is a little tip that I use. It is a great added benefit if you can handle it.

Tips on Techniques and More

As I have said before, start slowly. Maybe, fifteen minutes or so a day if that is all you can handle. Slowly, move that up to about thirty minutes a day. Now, this is where I have found a great added benefit and I want to share it with you. Before I do, let's talk about the "correct way" to walk.

Try to make sure that your heel is hitting the ground first with each step. Also, try to keep your elbows bent at about 90 degrees and keep a pace that is not too fast. Some say that you should walk at a speed at which you can do it and still carry on a conversation. I think that is sound advice.

Keep your head up and level with your body stance so that your shoulders are about even with your hips. This is going to keep your body evenly balanced and getting the most out of your walking experience.

Add a Little Weight

This small tip can be invaluable. I learned about this after talking to a Korean friend of mine.

Those little "dumbbells" you see in the sports stores (and, sold in major chain stores) can add a whole new dimension to walking. They are sold in small sizes and are a great investment in a walking regimen. (I have seen them in two, three, five, and seven-pound sizes.)

Once you are comfortable with your walking, add the smallest of these weights to your daily stroll. Of course, add one to each hand. Do not move up too fast. Make sure you are measuring how you feel with the lower levels.

If you find that this is working without causing any pain in either your elbows or shoulders, move up the weight range. I have a friend who uses seven-pounds in each hand daily. In fact, he does this for one hour every day. This man is 65 years old and he is in incredible shape. This is his exercise routine. This is the only exercise regimen he follows.

This is a wonderful addition to the general walking regimen if you do not experience any pain issues. It is especially good for those with arthritis.

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Fighting Inflammation in a Big Way

02/01/06 JR Rogers

Over the years, I have discussed the issue of inflammation and arthritis. If you read all of my Arthritis Chronicles, you get a pretty good picture of ways to contain pain which of course, is a consequence of inflammation when you suffer from OA.

I am Not a Book Reviewer

It goes without saying that my business is arthritis and how you can beat the pain, rehabilitate damaged cartilage, and lead a normal life. Of course, at the top of my list is using a very high-quality liquid Glucosamine. However, while that works standing alone for some, it does not for others. That is why I discuss the importance of diet and exercise as components of winning the battle.

A Great Book by a Top Gun

Dr. Andrew Weil recently released a great book that I know will help you. In fact, he discusses many of the same issues I have talked about but brings them more sharply into focus.

Now, arthritis does not discriminate and it can strike at any age. So, many of you who are regular readers of this column may think that this book does not apply to you. I assure you, if you suffer from arthritis, it does.

This book is titled, Healthy Aging. In this book, Dr. Weil discusses so many issues that apply to those who suffer from osteoarthritis that it goes beyond the scope of this chronicle. In a very relevant part, he talks about what he calls “The Anti-Inflammatory Diet.” This section describes eating habits that fight inflammation within your body and it is right on the money.

He also discusses exercise, injury avoidance for those who are very active and the pros and cons of certain foods and drinks. In brief, he brings you full circle into many of my past articles and lays it on the line. Following his advice can only assist those who have arthritis.

The full title is Healthy Aging, A Lifelong Guide to Your Physical and Spiritual Well Being. The last I checked online, you could buy a new copy for under $17.00.

Another Option

If that book is a little too heavy on your pocketbook or if you want to get only to the diet issues that assist those with OA, I would recommend The Mediterranean Diet. (Revised and Updated in 2004). Many of Dr. Weil’s diet recommendations are similar to this food regimen and it would have essentially the same anti-inflammatory characteristics if followed. The online price, I saw, was $6.99.

As I said, I am not in the business of reviewing books. But, either of these books provides a great deal of information that can help you in getting your arthritis inflammation under control.

We are coming into a new year once again, so let me wish all of you a very happy one.
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Glucosamine boosts the pain relieving power of ibuprofen

Article Date: 08 Jan 2004 - 0:00am (PDT)

ibuprofen, according to a new study by Temple University researchers in the Journal of Pharmacology and Experimental Therapeutics (JPET). This new drug combination could one day allow patients to take a lower dose and get the same pain relief with fewer unwanted side effects.

Ronald Tallarida, Ph.D., and Alan Cowan, Ph.D., of Temple's School of Medicine (Philadelphia, USA), and Robert Raffa, Ph.D., of Temple's School of Pharmacy, conducted the study 'Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice,' which was published in the November 2003 issue of JPET.

Ibuprofen is a non-steroidal anti-inflammatory drug, or NSAID. NSAIDs, which also include aspirin, are quite effective in relieving pain. They are so effective, in fact, that pain sufferers sometimes take higher and higher doses in hope of more pain relief.

High doses of NSAIDs, especially when taken over long periods of time, can cause gastrointestinal upset, such as heartburn, or even bleeding.

'Combining pain relievers into one pill can increase patient compliance, simplify prescribing, and improve efficacy without increasing side effects, or conversely, decrease side effects without losing efficacy,' said Raffa.

In addition to these benefits, drug combinations can also sometimes yield a totally unexpected effect, such as the magnification of a drug's powers. 'When this happens, a phenomenon known as drug synergism, it's like finding buried treasure,' added Tallarida.

Glucosamine, a naturally occurring substance in the body, which is also available in synthetic form over the counter, is used to treat osteoarthritis, a painful, degenerative joint disorder. While it has been shown to prevent and repair bone and cartilage damage, researchers have yet to demonstrate that glucosamine actually blocks pain.

'We embarked on this study with several questions: Can glucosamine actually block pain? And, can glucosamine improve the pain-relieving powers of other drugs when the two are combined?' said Tallarida.

First, the researchers confirmed that glucosamine, alone, does not block pain. It's believed that any pain-relieving properties of glucosamine are a side effect of its ability to repair bone damage.

Next, they combined glucosamine with a variety of NSAIDs at a variety of dosages. With several NSAIDs, including naproxen, the addition of glucosamine caused an additive effect, meaning the sum of each drug's properties.

When combined with aspirin or acetaminophen, the result was subadditive, or less than the sum of each drug's properties.

But when combined with ibuprofen, the researchers found pain relief was enhanced and therefore synergistic.

'The next step will be to study this drug combination in clinical trials to see whether it can enhance pain relief or offer pain relief using a lower dose of ibuprofen and therefore a lower risk of side effects,' said Cowan.

The researchers are also investigating other possible drug combinations for the potential relief of pain. Raffa and Tallarida played a role in the development of Ultracet, a combination of tramadol and acetominophen used in the treatment of pain. And Cowan contributed to the development of buprenorphine which, when combined with naloxone, is used in the treatment of opiate addiction.
Eryn Jelesiewicz
dobeck@temple.edu
Director
Public Relations, HSC

Temple University News and Media Relations
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NIH GAIT Study Supports Use Of Glucosamine And Chondroitin For Osteoarthritis Treatment

Article Date: 18 Feb 2006 - 14:00pm (PDT)

Arthritis experts and orthopaedic surgeons are discussing the results of the NIH study that shows a supplement to be as effective as the most expensive NSAIDs for moderate and severe pain from arthritis.

Dr. Kevin R. Stone, Chairman of the Stone Foundation for Sports Medicine and Arthritis Research in San Francisco pioneered the use of glucosamine in a beverage form for athletes and arthritis sufferers and is vocal about the results of this new study.

"The supplements glucosamine and chondroitin together, which are inexpensive and have zero negative side effects, performed as well as the very expensive and somewhat risky Celebrex," said Stone. "I believe the standard of care in medicine will now be to prescribe the supplements first and if they are not enough then to add additional medications," Stone said.

The GAIT (Glucosamine/Chondroitin Arthritis Intervention Trial) study funded by the National Institutes for Health (NIH)) evaluates the use of glucosamine and chondroitin in treating and preventing osteoarthritis. (nccam.nih.gov/news/19972000/121100/qa.htm#12)

Published study results indicate that the combination of glucosamine and chondroitin sulfate might be most effective in osteoarthritis patients who had moderate to severe knee pain.

As a physician treating patients with glucosamine and chondroitin for more than a decade, Dr. Stone says, "We recommend it for all our patients, both athletes and those with arthritis. Many of our patients with arthritis have given up using nonsteroidal anti-inflammatories because glucosamine has been effective for them." Stone prescribes 1,500 milligrams a day, taken all at once in beverage form.

WHO: Harvard- and UNC at Chapel Hill-educated Dr. Kevin R. Stone, founder of the Stone Clinic and chairman of the Stone Foundation for Sports Medicine and Arthritis Research (http://www.stoneclinic.com), and inventor and founder of Joint Juice, the first glucosamine beverage. Dr. Stone has provided commentary for media ranging from The Wall Street Journal and Newsweek to USAToday and CBSNews, is the author of numerous scientific articles, and is a frequent lecturer at leading forums and symposia. He is passionate and objective about the role of supplements in medical practice.

WHEN: Dr. Stone is available for phone and in-person interviews now.

WHERE: Dr. Stone is based in San Francisco.

Background

Initiated in 1998, GAIT is the first multicenter clinical trial in the United States to test the effects of the dietary supplements glucosamine and chondroitin for treatment of knee osteoarthritis.

The study tests whether glucosamine and chondroitin used separately or in combination are effective in reducing pain in patients with knee osteoarthritis. GAIT includes an additional study (or sub-study) that will assess whether glucosamine and chondroitin can reduce or halt the progression of knee osteoarthritis.

GAIT was designed to rigorously assess the effectiveness and safety of these supplements when taken separately or in combination. Almost 1,600 patients with painful knee osteoarthritis were recruited from 16 U.S. academic rheumatology centers for the study.

Results of previous studies in the medical literature have yielded conflicting results on the effectiveness of glucosamine and chondroitin as treatments for osteoarthritis. This study tested the short-term (6 months) effectiveness of glucosamine and chondroitin in reducing pain in a large number of patients with knee osteoarthritis.

The sub-study will also evaluate the impact of glucosamine and chondroitin on progression of knee osteoarthritis following an additional 18-month treatment regimen.

Stone Research Foundation
http://www.stoneclinic.com

More on Arthritis ....

Glucosamine Review and Potential Benefits

Something interesting happened as my triceps workouts continued in their intensity. After doing some triceps elbow extensions and numerous other elbow extension exercises, I began to feel effects of...

Author: Marc David
Date Posted: March 17, 2003

Something interesting happened as my triceps workouts continued in their intensity. After doing some triceps elbow extensions and numerous other elbow extension exercises, I began to feel effects of what is known as elbow tendonitis. The symptoms generally included a pain with any movement of my elbows. So much so, that even resting my arms on a chair began to have an associated soreness to the touch. Similar to my bicep tendonitis experience, the pain experienced was not normal. A bodybuilder who is tune with their muscles can tell the difference between an intense workout and an intensely painful workout.

This elbow tendonitis came about from an overuse of any exercise. With the increased weight, I eventually reached a peak of classic overuse of the joints. Not sure of a treatment, I did the first thing I could. Adjust my form. Keeping the elbows locked in on triceps movements is critical. It can alleviate if not remove the pressure on the joints when doing a very heavy exercise movement. This was my first elbow tendonitis treatment experiment.

Continuing week after week with my new form, the pain was less severe, but it was not a full treatment. Some of the elbow tendonitis symptoms became less painful but the general pain was always present. This has an acute effect on your motivation to continue to do exercises. Doing triceps exercises (dips, skull crushers, one arm and two arm overhead extensions, rope pushdowns) has always been something I look forward to with each arm workout. But with anything that is painful, your body doesn’t want to do it. In fact, continuing and pushing past the pain “no pain no gain” mantra, I would have eventually damaged my joints beyond repair.

After talking to a friend’s wife, she told me about her husband, who started taking Glucosamine for his joints. There are basically two kinds of people who need some type of cartilage therapy. Those who are suffering from osteoarthritis or athletes with overuse injuries. Considering he’s not very old and probably isn’t losing too much cartilage, I had to believe that it was working on cars daily and using his joints excessively (turning hands, manipulating small parts) that lead to his overuse of his finger joints and the pain associated. Thus began my short research and trial of a Glucosamine product to see what benefits Glucosamine might have and any possible side effects specific to me.

Glucosamine is a combination of sugar and amine. It’s found normally in cartilage and plays an important role in cartilage health and resiliency. As you naturally age, you lose some Glucosamine and that leads to the eventual thinning of the cartilage around the joints. Osteoarthritis defined as the deterioration of the cartilage in the joints. Glucosamine and Chondroitin are found naturally in your body. Chondroitin Sulfate helps draw water into the cartilage (that the Glucosamine is repairing) making it more elastic.

Glucosamine is derived from the shells of crabs and shrimp. Most studies show that taking approximately 500mg three times a day for a total of 1500mg is effective in improving joint health. Those who have damaged their joints to the point of little to no cartilage, or who have had cartilage surgically removed, probably won’t experience any benefits simply because it’s impossible to repair cartilage that no longer exists. Most oral Glucosamine is easily absorbed because the molecules are very small, easily diffused and water-soluble.

After viewing the brief research above, I began taking oral doses of Glucosamine and Chondroitin, 1500mg a day, 3 capsules. My first choice was AST’s ProFlex 750 Joint Support formula. I ended up going to Costco and getting Kirkland’s Glucosamine Sulfate product as well. Just so I could have a supply at home. Different products but basically, Glucosamine and some Chondroitin.

Within the first few days, my elbow tendonitis symptoms started to disappear. I’ve been taking this product for about 2 weeks now, and my workouts are back to their regular intensity. Taking a Glucosamine and Chondroitin supplement has all but cured my elbow tendonitis. From the research I could gather, it’s important to take these products when you still have a lot of cartilage to repair. It’s pretty ineffective to take it when the damage is too severe or the cartilage is absent. Glucosamine is a naturally occurring substance in the body with a primary function of stimulating the growth and repair of cartilage tissues.

About The Author

Marc David has a degree in Criminal Justice from Sacramento State, a 16 year history of non-competitive bodybuilding and is the owner of Freedomfly -the fitness network! For free fitness tools, discount supplements, fitness consultation, and workout routines, visit http://www.freedomfly.net
mrcd@freedomfly.net

Glucosamine Chondroitin & Arthritis

Many millions of people are affected by pain and suffering from Arthritis and research has shown that Glucosamine and Chondroitin sulphates combined have given these people new hope and relief from t...

Author: Alfred Jones
Date Posted: November 19, 2004

Many millions of people are affected by pain and suffering from Arthritis and research has shown that Glucosamine and Chondroitin sulphates combined have given these people new hope and relief from their painful ailments.

Many medicines are available to reduce pain, but some of them have serious side effects, some that have even proven to be fatal.

Both substances are Natural complex sugar like molecules that the body uses to rebuild cartilage and restore movement to Arthritic joints. It is important to remember that Glucosamine and Chondroitin are an amazingly safe and easy to use mixture, especially when compared with other forms of treatment.

Loss of cartilage can result in damage to the bone and the development of Osteoarthritis, which ends up as pain and disability. Cartilage is the key to healthy joints, and maintaining a healthy cartilage throughout life is critical to healthy joints and continued movement of joints.

As we age, or as the result of injuries, our ability to renew cartilage diminishes, causing damage to bone ends as they rub together. Glucosamine and Chondroitin can actually help to rebuild cartilage, therefore, improving joint health.

Taking the two compounds proves to be a very easy way of maintaining joint health and helping to alleviate pain and disability.

Cartilage rebuilding is a slow process, but with the right amounts of Glucosamine and Chondroitin benefits to mobility and pain relief can be seen within two to six weeks, it is recommended though that it should be taken daily for at least three months.

Engagement in mild or moderate exercise on a regular basis, would help in providing joint mobility.

Most users would need something like 1250mg to 1500mg of Glucosamine a day and about 1000mg to 1200mg of Chondroitin a day.

You should check with a Physician or Natural Health Care provider before commencing treatment.

Glyconutrients contain Glucosamine along with seven other sugars or polysaccharides.

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Osteoarthritis and Glucosamine

Osteoarthritis (OA) is the most common of all the arthritic conditions today. OA is a joint disease related to aging and overuse causing a breakdown and eventually a loss of the cartilage in a joint....

Author: Allan Sadi
Date Posted: October 10, 2005

Osteoarthritis (OA) is the most common of all the arthritic conditions today. OA is a joint disease related to aging and overuse causing a breakdown and eventually a loss of the cartilage in a joint. Cartilage is a protein that protects the ends of bones in a joint. OA affects mostly weight-bearing joints such as the hips, knees, ankles, and feet. However, the hands, shoulders, and spine are also at risk.

Causes and risk factors:

  1. Aging causes an increase in the water content of the cartilage and a decrease in the protein content putting the joint at risk for degeneration
  2. Overuse of the joints cause inflammation and eventually wear and tear
  3. Previous injuries or fractures to a bone or joint increases the risk of early OA
  4. Obesity leads to early degeneration due to high stresses on the weight-bearing joints
  5. Gout, congenital abnormalities, and hormonal disorders

Signs and Symptoms:

  1. Pain at the joint worsening at the end of the day
  2. Stiffness at the joint
  3. Swelling
  4. Heat
  5. Crepitus (grinding sounds)
  6. Loss of function

Treatment

  1. Rest
  2. Light or no-impact exercise to strengthen muscles surrounding the joint
  3. Physiotherapy and occupational therapy
  4. Support devices (canes, walkers, splints)
  5. Weight loss through diet and exercise
  6. Total joint replacement surgery (i.e. hip, knee, shoulder)
  7. Heat and ice
  8. Cortisone injection
  9. Non-steroid anti-inflammatory drugs (NSAIDs)
  10. Pain relievers/analgesics (aspirin, ibuprofen, acetaminophen)
  11. A series of hyaluronic acid injections (Synvisc, Hyalgan) into the joint
  12. Glucosamine

Glucosamine:

Glucosamine is found naturally in the body and is extremely effective in decreasing OA symptoms on a long-term basis. Glucosamine has been shown to rebuild cartilage and decrease joint deterioration with NO side-effects! NSAIDs, on the other hand, can cause stomach bleeding, intestinal damage, and liver failure. Glucosamine treats the culprit causing the problem, not just the symptoms.

What you should look for when shopping for Glucosamine:

  1. Liquid form as opposed to pill or tablet because it's absorbed easier
  2. The dose size should be 1000 mg of Glucosamine
  3. The cost for a month's worth should be between 30-50$
  4. Look for other ingredients included in the bottle such as Chondroitin Sulfate, MSM, Omega 3 Fatty Acids, Manganese Ascorbate, Aloe Vera, Boswellia Serrata (Boswellin), Niacinamide, Vitamin C, Vitamin A, Vitamin E, Bromelaine, and Yucca.

***Be patient and you should feel a decrease in symptoms in 3-4 weeks as long as you have also incorporated rest, mild exercise, and weight loss (if needed) into your lifestyle.

About The Author

Allen Sadi from Physiotherapy Tips (www.physiotalk.com) Is:
• B.Sc Physiotherapy
• B.Sc Athletic Therapy
• Outstanding O.P.P.Q. member

Glucosamine - The Arthritis Cure?

Glucosamine sulphate has been around a long time now and as each year goes by more and more claims are made telling us about this miracle joint lubricant. Are all the claims true? Will it cure Arthr...

Author: Bill Morrison
Date Posted: November 05, 2005

Glucosamine sulphate has been around a long time now and as each year goes by more and more claims are made telling us about this miracle joint lubricant. Are all the claims true? Will it cure Arthritis? What is Glucosamine anyway? And what about Chondroitin?

Glucosamine is a naturally produced amino sugar which is found in small amounts in foods. It plays an important role in maintaining the cartilage gel-like material between our joints. The body also produces a carbohydrate called Chondroitin, which is thought to promote water retention and elasticity as well as blocking the enzymes that break down cartilage.

As we get older the body's ability to manufacture and synthesize Glucosamine and Chondroitin decreases. This probably contributes to the joint problems we have all come to associate with growing old, a fact that health food companies did not take long to latch on to.

Although studies have been carried out in numerous countries to try to prove conclusively that Glucosamine is effective in treating arthritis and joint problems there have been an equal number of questions raised about the methodology of many of these studies. One such study, in Europe, took X-rays to measure the size of the gap in the knee joint before and after taking Glucosamine. Even though the results showed that the size of the gap was significantly larger, in a group of people taking Glucosamine compared to a group taking NSAIDs, critics said that the study was not large enough to draw firm conclusions. They also claimed the X-ray evidence was too difficult to interpret.

Many Vets and pet owners have been using Glucosamine to treat joint problems in horses and dogs for a number of years now. They swear by the effectiveness of this form of treatment for their animals. While there is no placebo effect in animals it is equally difficult to find well documented, and conclusive, scientific evidence to confirm the effectiveness of Glucosamine.

While there might be limited good, accredited, scientific proof as to the effectiveness of Glucosamine there is an abundance of people as well as pet owners who swear by the effectiveness of Glucosamine. Even though Glucosamine is often used in combination with other supplements, or treatments, the general feeling among most users is that it does help. Results of empirical studies in various countries have shown that arthritis sufferers report significant improvements when taking Glucosamine supplements. The same is also true for people who have other types of joint injuries or back problems. Some countries now sanction Glucosamine as a treatment for people with mild to moderately severe osteoarthritis.

To date no study has found any serious side effects from either Glucosamine or Chondroitin when taken as a supplement in humans. However people with diabetes are advised to keep a check on their blood-sugar level. While there have been no reports of allergic reactions to Glucosamine, since it's made from shellfish shells, it may not be suitable for people with seafood allergies. It may also increase a person's daily salt intake level - something people with high blood pressure may want to watch. Chondroitin on the other hand may sometimes cause bleeding in people with bleeding disorders or taking blood-thinning drugs. Like many supplements insufficient data is available about the long term effects and hence it should be not be taken by children, or pregnant or breastfeeding mothers.

The United States Food and Drug Administration embarked on a study involving 1500 people earlier in 2005 to determine the effects of Glucosamine and Chondroitin on people with arthritic problems.

There are many claims that taking Glucosamine will slow and possibly halt osteoarthritis-related damage to joints, speed healing of strains and sprains, control back pain and help promote healthy aging. Whether this is true or not, the overall rhetorical evidence is probably stacked in favour of the use of Glucosamine as a supplement - so maybe it's worth a try - for a trial period anyway!

This information in this article should not be used to diagnose, treat, or prevent any disease. You should always consult with your health care professional especially relating suitability of supplements or drugs and on all health matters that may require diagnosis or medical attention.

About The Author

Bill Morrison has his own website http://www.help4urback.com where he describes his own personal experiences coping with lower back pain and sciatica. He also includes personal recommendations for people who suffer from sciatica or lower back pain including what books to buy, TENs machines, and what web sites to check out.